49ers vs Bills Prediction, Bet Builder Tips & Odds

By Paul Thomas, Senior NFL Analyst | Published: 5 months ago | 4 min read

San Francisco 49ers

American Football NFL Highmark Stadium Mon 2 Dec 08:20

Buffalo Bills

  1. Prediction
  2. Bet Builder
  3. Odds
  4. Player Props
  5. Stats
  6. Team News
  7. Lineups
  8. Injuries
  9. Standings

Roll the Dice on Teams Scoring Over 44.5

There could be plenty of points when the Bills clash with the Niners, with our prediction being Over 44.5 points in total. Odds of 1.91 look worth taking for this outcome.

Bills Beat Niners in their Last Clash

San Francisco 49ers have now lost back-to-back games. On the road in their previous appearance, Green Bay Packers won 38-10 at Lambeau Field. The 49ers gained 44 rushing and 197 passing yards, making 241 yards in total. They picked up 11 first downs and scored 1 passing TD.

Buffalo Bills were winners for the sixth straight time in their last game. Landing a 30-21 home victory against Kansas City Chiefs at Highmark Stadium. The Bills gained 104 rushing and 262 passing yards, making 366 yards in total. They scored 1 passing TD’s and 3 rushing TD. 4 touchdowns in total.

It was the Bills who came out on top when they last played the Niners. At State Farm Stadium, a 34-24 win was recorded.

Quarterbacks

Brock Purdy
Josh Allen

Expert NFL Analysis

Our expert NFL handicappers study the latest form, while injuries and suspensions can also affect the potential outcome. Before coming up with a verdict, we combine this data with the latest stats.

Key 49ers vs Bills stats:

  • The 44.5 line has been covered in 13 of the last 20 49ers games.
  • The 44.5 line has been covered in 7 of the last 11 49ers games this season.
  • The 44.5 line has been covered in 4 of the last 5 Bills games at home this season.
  • The 44.5 line has been covered in 7 of the last 10 Bills games at home.
  • The 44.5 line has been covered in the last 3 Bills games this season.

49ers vs Bills Prediction

We’re surprised that the total line is 44.5 and it’s all about going for the Overs option when these NFL teams take to the field. Take the 1.91 and cheer on points.

If you’re confident with your Over pick but want more juice from your wager, then a Bet Builder can offer the chance to add in other selections for a bigger potential return.

Over 44.5 Probability

The sportsbooks imply that our pick has a 52.4% prospect of winning. However, our research has found that the actual probability is closer to 60%. It is the reason why we are recommending this wager.

Our Pick

Over 44.5 Points @ 1.91 Bet Now bet365 logo
Gamble responsibly 18+. All odds are correct at time of publishing and are subject to change. To use the Bookmaker Live Streaming services you will need to be logged in and have a funded account or to have placed a bet in the last 24 hours. Geo-restrictions apply.
Published 13:26, 30 November 2024

49ers vs Bills Bet Builder Tips

Totals Over 44.5
Anytime Touchdown Christian McCaffrey
Receiving Yards Dawson Knox Over 24.5

We’ve compiled a same game parlay that includes Over 44.5, combined with Christian McCaffrey to score a touchdown and Dawson Knox (Bills) Over 24.5 receiving yards.

There are lots of options when you place a bet builder. You can go through the football lines and identify your favorite picks before combining the odds on the bet slip. Personalised wagering doesn’t come any better.

T&C apply. Gamble responsibly 18+

Correct Score Prediction

49ers 49ers logo 20 - 34 Bills logo Bills

Should you wish to go for a speculative wager, try the Bills to win 34-20 on the correct score lines. This should be a fun bet which could potentially yield a big return.

49ers vs Bills Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Expecting a Bills Victory

With the sportsbooks giving them a 76% probability of winning this game, Buffalo Bills might be a popular parlay pick. That is reflected in their 1.32 Moneyline betting odds. At 3.50, San Francisco 49ers are regarded as having a lower probability of winning.

6.5 is the spread and 44.5 is the total points line. Having a wager on the Totals is one of the most popular NFL bets. If you’re going for Over 44.5, then the odds are 1.83.

The good news is that you can access a wide range of game lines and team props for every National Football League clash. The betting sites offer a great selection of pre-game and in-game wagering options.

Player Props

The best gambling sites offer player and quarterback prop betting to their customers. These can be a great alternative if you want to focus on an individual’s performance within a game and it often involves wagering over or under a line.

Christian McCaffrey Favorite to Score First Touchdown

The Anytime Touchdown betting indicates that Christian McCaffrey has odds of %anytime_odds%. He is available at %first_odds% to score the first TD which makes him favorite.

Touchdown

Christian McCaffrey (49ers)
First TD
5.20
Anytime TD
1.66
bet365 Logo
Amari Cooper (Bills)
First TD
9.50
Anytime TD
2.65
bet365 Logo

Receiving Yards

Rushing Yards

Passing Yards

Best Betting Offers

Last 5 & H2H

Team Stats

Latest regular season and playoff games stats.

San Francisco 49ers logo San Francisco 49ers Stats

Buffalo Bills logo Buffalo Bills Stats

Moneyline

  • 4 wins and 6 defeats in the last 10 games
  • 6 wins and 4 defeats in the last 10 games on the road

Moneyline

  • 8 wins and 2 defeats in the last 10 games
  • 9 wins and 1 defeat in the last 10 home games

Point Spread

Point Spread

Total Points

Total Points

Game Stats

Last 10 Games

Game Stats

Last 10 Games
Last 10 Games on the Road
Last 10 Home Games

Team News

San Francisco 49ers @ Buffalo Bills Lineups

Buffalo Bills

Manager:
Sean McDermott
1
Curtis Samuel
2
Tyler Bass
8
Sam Martin
11
Mitch Trubisky
18
Amari Cooper
22
Ray Davis
24
Cole Bishop
26
Ty Johnson
29
Brandon Codrington
32
Nicholas Morrow
39
Cameron Lewis
40
Von Miller
41
Reggie Gilliam
42
Dorian Williams
44
Joe Andreessen
46
Ja'Marcus Ingram
62
Sedrick Van Pran-Granger
69
Reid Ferguson
70
Alec Anderson
71
Quinton Jefferson
74
Ryan Van Demark
84
Zach Davidson
89
Jalen Virgil
97
Jordan Phillips
98
Austin Johnson
99
Casey Toohill

San Francisco 49ers

Manager:
Kyle Shanahan
4
Jake Moody
5
Joshua Dobbs
9
Brayden Willis
14
Ricky Pearsall
18
Chris Conley
19
Jacob Cowing
22
Isaac Yiadom
24
Jordan Ponchez-Mason
30
George Odum
31
Isaac Guerendo
33
Rock Ya-Sin
35
Nick McCloud
40
Pat O'Donnell
41
Jalen Graham
43
Tashaun Gipson
46
Taybor Pepper
50
Khalil Davis
51
Robert Beal Jr.
60
Sebastian Gutierrez
63
Nick Zakelj
74
Spencer Burford
82
Eric Saubert
88
Jake Tonges
90
Kevin Givens
93
Kalia Davis
94
Yetur Gross-Matos

Buffalo Bills Substitutes

  • 3 Damar Hamlin
  • 4 James Cook
  • 7 Taron Johnson
  • 9 Taylor Rapp
  • 10 Khalil Shakir
  • 13 Mack Hollins
  • 17 Josh Allen
  • 31 Rasul Douglas
  • 43 Terrel Bernard
  • 47 Christian Benford
  • 50 Gregory Rousseau
  • 57 A.J. Epenesa
  • 58 Matt Milano
  • 64 O'Cyrus Torrence
  • 66 Connor McGovern
  • 73 Dion Dawkins
  • 76 David Edwards
  • 79 Spencer Brown
  • 85 Quintin Morris
  • 88 Dawson Knox
  • 91 Ed Oliver
  • 92 DaQuan Jones

San Francisco 49ers Substitutes

  • 0 Renardo Green
  • 1 Deebo Samuel
  • 6 Malik Mustapha
  • 7 Charvarius Ward
  • 13 Brock Purdy
  • 15 Jauan Jennings
  • 23 Christian McCaffrey
  • 27 Ji'Ayir Brown
  • 44 Kyle Juszczyk
  • 53 Dee Winters
  • 54 Fred Warner
  • 56 Leonard Floyd
  • 59 De'Vondre Campbell
  • 64 Jake Brendel
  • 68 Colton McKivitz
  • 69 Evan Anderson
  • 76 Jaylon Moore
  • 77 Dominick Puni
  • 78 Ben Bartch
  • 85 George Kittle
  • 91 Sam Okuayinonu
  • 99 Maliek Collins

San Francisco 49ers Injuries

Type
Name
Info
Brandon Aiyuk
Knee - ACL + MCL
Aaron Banks
Concussion
Tatum Bethune
Knee - MCL
Nick Bosa
Hip
Chris Conley
Knee
Jordan Elliott
Concussion
Jon Feliciano
Knee
Demetrius Flannigan-Fowles
Knee
Kevin Givens
Groin
Renardo Green
Neck
Dre Greenlaw
Achilles
Javon Hargrave
Triceps
Talanoa Hufanga
Wrist
Drake Jackson
Knee
Deommodore Lenoir
Knee
Darrell Luter
Pelvis
Elijah Mitchell
Hamstring
Brock Purdy
Shoulder
Curtis Robinson
Knee - ACL
Ambry Thomas
Forearm
Trent Williams
Ankle
Mitch Wishnowsky
Back

Buffalo Bills Injuries

Type
Name
Info
Shane Buechele
Neck
DeWayne Carter
Wrist
Travis Clayton
Shoulder
Keon Coleman
Wrist
Tommy Doyle
Knee
Tylan Grable
Abdomen
Dalton Kincaid
Knee
Matt Milano
Biceps
Brandon Shell
Undisclosed
Dawuane Smoot
Wrist
Baylon Spector
Calf

Previous San Francisco 49ers Lineups

25 Nov NFL
49ers 10-38 Packers
18 Nov NFL
Seahawks 20-17 49ers
11 Nov NFL
49ers 23-20 Buccaneers
28 Oct NFL
Cowboys 24-30 49ers
21 Oct NFL
Chiefs 28-18 49ers
11 Oct NFL
49ers 36-24 Seahawks
07 Oct NFL
Cardinals 24-23 49ers
30 Sep NFL
Patriots 13-30 49ers
23 Sep NFL
49ers 24-27 Rams
16 Sep NFL
49ers 17-23 Vikings

Previous Buffalo Bills Lineups

18 Nov NFL
Chiefs 21-30 Bills
11 Nov NFL
Bills 30-20 Colts
04 Nov NFL
Dolphins 27-30 Bills
28 Oct NFL
Bills 31-10 Seahawks
21 Oct NFL
Titans 10-34 Bills
15 Oct NFL
Bills 23-20 Jets
07 Oct NFL
Bills 20-23 Texans
30 Sep NFL
Bills 10-35 Ravens
24 Sep NFL
Jaguars 10-47 Bills
13 Sep NFL
Bills 31-10 Dolphins

NFL Standings Select Season

AFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bills 13 4 0 0.765 525 368 157 8-0-0 5-4-0 5-1-0 9-3-0 3-2-0 1L
Dolphins 8 9 0 0.471 345 364 -19 5-3-0 3-6-0 3-3-0 6-6-0 3-2-0 1L
Jets 5 12 0 0.294 338 404 -66 3-5-0 2-7-0 2-4-0 5-7-0 2-3-0 1W
Patriots 4 13 0 0.235 289 417 -128 2-6-0 2-7-0 2-4-0 3-9-0 1-4-0 1W
AFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Ravens 12 5 0 0.706 518 361 157 6-2-0 6-3-0 4-2-0 8-4-0 4-1-0 4W
Steelers 10 7 0 0.588 380 347 33 5-3-0 5-4-0 3-3-0 7-5-0 1-4-0 4L
Bengals 9 8 0 0.529 472 434 38 3-5-0 6-3-0 3-3-0 6-6-0 5-0-0 5W
Browns 3 14 0 0.176 258 435 -177 2-6-0 1-8-0 2-4-0 3-9-0 0-5-0 6L
AFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Texans 10 7 0 0.588 372 372 0 5-3-0 5-4-0 5-1-0 8-4-0 3-2-0 1W
Colts 8 9 0 0.471 377 427 -50 5-3-0 3-6-0 3-3-0 7-5-0 3-2-0 1W
Jaguars 4 13 0 0.235 320 435 -115 3-5-0 1-8-0 3-3-0 4-8-0 2-3-0 1L
Titans 3 14 0 0.176 311 460 -149 1-7-0 2-7-0 1-5-0 3-9-0 0-5-0 6L
AFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Chiefs 15 2 0 0.882 385 326 59 8-0-0 7-2-0 5-1-0 10-2-0 4-1-0 1L
Chargers 11 6 0 0.647 402 301 101 5-3-0 6-3-0 4-2-0 8-4-0 3-2-0 3W
Broncos 10 7 0 0.588 425 311 114 6-2-0 4-5-0 3-3-0 6-6-0 3-2-0 1W
Raiders 4 13 0 0.235 309 434 -125 2-6-0 2-7-0 0-6-0 3-9-0 2-3-0 1L
NFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 14 3 0 0.824 463 303 160 8-1-0 6-2-0 5-1-0 9-3-0 4-1-0 2W
Commanders 12 5 0 0.706 485 391 94 7-2-0 5-3-0 4-2-0 9-3-0 5-0-0 5W
Cowboys 7 10 0 0.412 350 468 -118 2-7-0 5-3-0 3-3-0 5-7-0 2-3-0 2L
Giants 3 14 0 0.176 273 415 -142 1-8-0 2-6-0 0-6-0 1-11-0 1-4-0 1L
NFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Lions 15 2 0 0.882 564 342 222 7-2-0 8-0-0 6-0-0 11-1-0 4-1-0 3W
Vikings 14 3 0 0.824 432 332 100 8-1-0 6-2-0 4-2-0 9-3-0 4-1-0 1L
Packers 11 6 0 0.647 460 338 122 6-3-0 5-3-0 1-5-0 6-6-0 2-3-0 2L
Bears 5 12 0 0.294 310 370 -60 4-5-0 1-7-0 1-5-0 3-9-0 1-4-0 1W
NFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Buccaneers 10 7 0 0.588 502 385 117 5-4-0 5-3-0 4-2-0 8-4-0 4-1-0 2W
Falcons 8 9 0 0.471 389 423 -34 4-5-0 4-4-0 4-2-0 7-5-0 2-3-0 2L
Saints 5 12 0 0.294 338 398 -60 3-6-0 2-6-0 2-4-0 4-8-0 1-4-0 4L
Panthers 5 12 0 0.294 341 534 -193 3-6-0 2-6-0 2-4-0 4-8-0 2-3-0 1W
NFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Rams 10 7 0 0.588 367 386 -19 5-4-0 5-3-0 4-2-0 6-6-0 4-1-0 1L
Seahawks 10 7 0 0.588 375 368 7 3-6-0 7-1-0 4-2-0 6-6-0 3-2-0 2W
Cardinals 8 9 0 0.471 400 379 21 6-3-0 2-6-0 3-3-0 4-8-0 2-3-0 1W
49ers 6 11 0 0.353 389 436 -47 4-5-0 2-6-0 1-5-0 4-8-0 1-4-0 4L
AFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Chiefs 15 2 0 0.882 385 326 59 8-0-0 7-2-0 5-1-0 10-2-0 4-1-0 1L
Bills 13 4 0 0.765 525 368 157 8-0-0 5-4-0 5-1-0 9-3-0 3-2-0 1L
Ravens 12 5 0 0.706 518 361 157 6-2-0 6-3-0 4-2-0 8-4-0 4-1-0 4W
Texans 10 7 0 0.588 372 372 0 5-3-0 5-4-0 5-1-0 8-4-0 3-2-0 1W
Chargers 11 6 0 0.647 402 301 101 5-3-0 6-3-0 4-2-0 8-4-0 3-2-0 3W
Steelers 10 7 0 0.588 380 347 33 5-3-0 5-4-0 3-3-0 7-5-0 1-4-0 4L
Broncos 10 7 0 0.588 425 311 114 6-2-0 4-5-0 3-3-0 6-6-0 3-2-0 1W
Bengals 9 8 0 0.529 472 434 38 3-5-0 6-3-0 3-3-0 6-6-0 5-0-0 5W
Colts 8 9 0 0.471 377 427 -50 5-3-0 3-6-0 3-3-0 7-5-0 3-2-0 1W
Dolphins 8 9 0 0.471 345 364 -19 5-3-0 3-6-0 3-3-0 6-6-0 3-2-0 1L
Jets 5 12 0 0.294 338 404 -66 3-5-0 2-7-0 2-4-0 5-7-0 2-3-0 1W
Raiders 4 13 0 0.235 309 434 -125 2-6-0 2-7-0 0-6-0 3-9-0 2-3-0 1L
Jaguars 4 13 0 0.235 320 435 -115 3-5-0 1-8-0 3-3-0 4-8-0 2-3-0 1L
Titans 3 14 0 0.176 311 460 -149 1-7-0 2-7-0 1-5-0 3-9-0 0-5-0 6L
Patriots 4 13 0 0.235 289 417 -128 2-6-0 2-7-0 2-4-0 3-9-0 1-4-0 1W
Browns 3 14 0 0.176 258 435 -177 2-6-0 1-8-0 2-4-0 3-9-0 0-5-0 6L
NFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Lions 15 2 0 0.882 564 342 222 7-2-0 8-0-0 6-0-0 11-1-0 4-1-0 3W
Eagles 14 3 0 0.824 463 303 160 8-1-0 6-2-0 5-1-0 9-3-0 4-1-0 2W
Rams 10 7 0 0.588 367 386 -19 5-4-0 5-3-0 4-2-0 6-6-0 4-1-0 1L
Buccaneers 10 7 0 0.588 502 385 117 5-4-0 5-3-0 4-2-0 8-4-0 4-1-0 2W
Vikings 14 3 0 0.824 432 332 100 8-1-0 6-2-0 4-2-0 9-3-0 4-1-0 1L
Commanders 12 5 0 0.706 485 391 94 7-2-0 5-3-0 4-2-0 9-3-0 5-0-0 5W
Packers 11 6 0 0.647 460 338 122 6-3-0 5-3-0 1-5-0 6-6-0 2-3-0 2L
Seahawks 10 7 0 0.588 375 368 7 3-6-0 7-1-0 4-2-0 6-6-0 3-2-0 2W
Falcons 8 9 0 0.471 389 423 -34 4-5-0 4-4-0 4-2-0 7-5-0 2-3-0 2L
Cowboys 7 10 0 0.412 350 468 -118 2-7-0 5-3-0 3-3-0 5-7-0 2-3-0 2L
Cardinals 8 9 0 0.471 400 379 21 6-3-0 2-6-0 3-3-0 4-8-0 2-3-0 1W
49ers 6 11 0 0.353 389 436 -47 4-5-0 2-6-0 1-5-0 4-8-0 1-4-0 4L
Saints 5 12 0 0.294 338 398 -60 3-6-0 2-6-0 2-4-0 4-8-0 1-4-0 4L
Bears 5 12 0 0.294 310 370 -60 4-5-0 1-7-0 1-5-0 3-9-0 1-4-0 1W
Panthers 5 12 0 0.294 341 534 -193 3-6-0 2-6-0 2-4-0 4-8-0 2-3-0 1W
Giants 3 14 0 0.176 273 415 -142 1-8-0 2-6-0 0-6-0 1-11-0 1-4-0 1L
NFL Team W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Lions 15 2 0 0.882 564 342 222 7-2-0 8-0-0 6-0-0 11-1-0 4-1-0 3W
Chiefs 15 2 0 0.882 385 326 59 8-0-0 7-2-0 5-1-0 10-2-0 4-1-0 1L
Vikings 14 3 0 0.824 432 332 100 8-1-0 6-2-0 4-2-0 9-3-0 4-1-0 1L
Eagles 14 3 0 0.824 463 303 160 8-1-0 6-2-0 5-1-0 9-3-0 4-1-0 2W
Bills 13 4 0 0.765 525 368 157 8-0-0 5-4-0 5-1-0 9-3-0 3-2-0 1L
Ravens 12 5 0 0.706 518 361 157 6-2-0 6-3-0 4-2-0 8-4-0 4-1-0 4W
Commanders 12 5 0 0.706 485 391 94 7-2-0 5-3-0 4-2-0 9-3-0 5-0-0 5W
Packers 11 6 0 0.647 460 338 122 6-3-0 5-3-0 1-5-0 6-6-0 2-3-0 2L
Chargers 11 6 0 0.647 402 301 101 5-3-0 6-3-0 4-2-0 8-4-0 3-2-0 3W
Broncos 10 7 0 0.588 425 311 114 6-2-0 4-5-0 3-3-0 6-6-0 3-2-0 1W
Texans 10 7 0 0.588 372 372 0 5-3-0 5-4-0 5-1-0 8-4-0 3-2-0 1W
Rams 10 7 0 0.588 367 386 -19 5-4-0 5-3-0 4-2-0 6-6-0 4-1-0 1L
Steelers 10 7 0 0.588 380 347 33 5-3-0 5-4-0 3-3-0 7-5-0 1-4-0 4L
Seahawks 10 7 0 0.588 375 368 7 3-6-0 7-1-0 4-2-0 6-6-0 3-2-0 2W
Buccaneers 10 7 0 0.588 502 385 117 5-4-0 5-3-0 4-2-0 8-4-0 4-1-0 2W
Bengals 9 8 0 0.529 472 434 38 3-5-0 6-3-0 3-3-0 6-6-0 5-0-0 5W
Cardinals 8 9 0 0.471 400 379 21 6-3-0 2-6-0 3-3-0 4-8-0 2-3-0 1W
Falcons 8 9 0 0.471 389 423 -34 4-5-0 4-4-0 4-2-0 7-5-0 2-3-0 2L
Colts 8 9 0 0.471 377 427 -50 5-3-0 3-6-0 3-3-0 7-5-0 3-2-0 1W
Dolphins 8 9 0 0.471 345 364 -19 5-3-0 3-6-0 3-3-0 6-6-0 3-2-0 1L
Cowboys 7 10 0 0.412 350 468 -118 2-7-0 5-3-0 3-3-0 5-7-0 2-3-0 2L
49ers 6 11 0 0.353 389 436 -47 4-5-0 2-6-0 1-5-0 4-8-0 1-4-0 4L
Panthers 5 12 0 0.294 341 534 -193 3-6-0 2-6-0 2-4-0 4-8-0 2-3-0 1W
Bears 5 12 0 0.294 310 370 -60 4-5-0 1-7-0 1-5-0 3-9-0 1-4-0 1W
Saints 5 12 0 0.294 338 398 -60 3-6-0 2-6-0 2-4-0 4-8-0 1-4-0 4L
Jets 5 12 0 0.294 338 404 -66 3-5-0 2-7-0 2-4-0 5-7-0 2-3-0 1W
Jaguars 4 13 0 0.235 320 435 -115 3-5-0 1-8-0 3-3-0 4-8-0 2-3-0 1L
Raiders 4 13 0 0.235 309 434 -125 2-6-0 2-7-0 0-6-0 3-9-0 2-3-0 1L
Patriots 4 13 0 0.235 289 417 -128 2-6-0 2-7-0 2-4-0 3-9-0 1-4-0 1W
Browns 3 14 0 0.176 258 435 -177 2-6-0 1-8-0 2-4-0 3-9-0 0-5-0 6L
Giants 3 14 0 0.176 273 415 -142 1-8-0 2-6-0 0-6-0 1-11-0 1-4-0 1L
Titans 3 14 0 0.176 311 460 -149 1-7-0 2-7-0 1-5-0 3-9-0 0-5-0 6L

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